Compile Data Set for Download or QSAR
maximum 50k data
Found 455 of ic50 data for polymerid = 347,50006958,7989
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118519(CHEMBL3617050)
Affinity DataIC50:  0.0620nMAssay Description:Inhibition of NaV1.4 channel (unknown origin) expressed in Xenopus laevis oocytes by two-electrode oocyte voltage-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50595862(CHEMBL5189924)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50595859(CHEMBL5192731)
Affinity DataIC50:  2nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Rattus norvegicus (Rat))
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50:  2.40nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM70937(US9546164, 100 | US9694002, 100)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of full length human Nav1.4 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM145285(US8952169, 64 | US9771376, Example 64)
Affinity DataIC50:  8.5nMAssay Description:Inhibition of full length human Nav1.4 expressed in HEK cells by whole cell voltage clamp analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Rattus norvegicus (Rat))
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM190239(US9174999, Table 1, Compound 7)
Affinity DataIC50:  15nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50595863(CHEMBL5184022)
Affinity DataIC50:  15nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM190233(US9174999, Table 1, Compound 1)
Affinity DataIC50:  19nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Rattus norvegicus (Rat))
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM190241(US9174999, 10)
Affinity DataIC50:  19nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077469(CHEMBL3416888)
Affinity DataIC50:  20nMAssay Description:Inhibition of human NaV1.4 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Rattus norvegicus (Rat))
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM190238(US9174999, Table 1, Compound 6)
Affinity DataIC50:  22.5nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450609(CHEMBL4170712)
Affinity DataIC50:  23nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450603(CHEMBL4159473)
Affinity DataIC50:  23nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Rattus norvegicus (Rat))
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM190234(US9174999, 8)
Affinity DataIC50:  26nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50051073(CHEMBL3318132)
Affinity DataIC50:  30nMAssay Description:Inhibition of human NaV1.4 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50344821(10-hydroxymethyl-5-imino-(2S)-12,13-dioxa-4,6-diaz...)
Affinity DataIC50: <30nMAssay Description:Inhibition of voltage-gated Na channel 1.4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50595856(CHEMBL5205795)
Affinity DataIC50:  32nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50595857(CHEMBL5192925)
Affinity DataIC50:  33nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450602(CHEMBL4167379)
Affinity DataIC50:  37nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450610(CHEMBL4160074)
Affinity DataIC50:  39nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Rattus norvegicus (Rat))
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM60830(US9174999, 13)
Affinity DataIC50:  46nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50595858(CHEMBL5204844)
Affinity DataIC50:  51nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450597(CHEMBL4160943)
Affinity DataIC50:  52nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450580(CHEMBL4169884)
Affinity DataIC50:  53nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Rattus norvegicus (Rat))
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM190237(US9174999, Table 1, Compound 5)
Affinity DataIC50:  55nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 4 subunit alpha(Rattus norvegicus (Rat))
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM50520482(CHEMBL4562161)
Affinity DataIC50:  69nMAssay Description:Inhibition of rat Nav1.4 expressed in HEK293 cells at -80 mV holding potential by whole cell patch-clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50164184(CHEMBL3798824)
Affinity DataIC50:  70nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077805(CHEMBL3416931)
Affinity DataIC50:  70nMAssay Description:Inhibition of human NaV1.4 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450583(CHEMBL4174312)
Affinity DataIC50:  72nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50595861(CHEMBL5204544)
Affinity DataIC50:  75nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50051073(CHEMBL3318132)
Affinity DataIC50:  79nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Rattus norvegicus (Rat))
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM190240(US9174999, 9)
Affinity DataIC50:  83nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium channel protein type 4 subunit alpha(Rattus norvegicus (Rat))
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM50505256(CHEMBL4547737)
Affinity DataIC50:  83nMAssay Description:Inhibition of recombinant rat Nav1.4 expressed in CHO cells by whole cell voltage clamp electrophysiology recordingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetSodium channel protein type 4 subunit alpha(Rattus norvegicus (Rat))
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM190243(US9174999, 12)
Affinity DataIC50:  87nMAssay Description:In initial studies, we designed a set of molecules with branching at the nitrogen of the carbamate side chain as well as the carbon adjacent to the n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450590(CHEMBL4163637)
Affinity DataIC50:  89nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50118518(CHEMBL3617066)
Affinity DataIC50:  90nMAssay Description:Inhibition of mouse NaV1.4 channel by two-electrode voltage-clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Rattus norvegicus (Rat))
The Board of Trustees of The Leland Stanford Junior University

US Patent
LigandPNGBDBM50242400(CCNCSSKWCRDHSRCC | CHEMBL525818)
Affinity DataIC50:  90nMAssay Description:Inhibition of rat Nav1.4 channel expressed in Xenopus oocytes by whole cell voltage clamp techniqueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077803(CHEMBL3416933)
Affinity DataIC50:  90nMAssay Description:Inhibition of human NaV1.4 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450601(CHEMBL4162835)
Affinity DataIC50:  92nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50051088(CHEMBL3318147)
Affinity DataIC50:  93nMAssay Description:Inhibition of human Nav1.4 stably expressed in cells with train pulses to -20 mV at 0.1 Hz and holding potential of -95 mV by whole-cell Qube-automat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077833(CHEMBL3416926)
Affinity DataIC50:  100nMAssay Description:Inhibition of human NaV1.4 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077810(CHEMBL3416930)
Affinity DataIC50:  100nMAssay Description:Inhibition of human NaV1.4 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450582(CHEMBL4167720)
Affinity DataIC50:  102nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50450581(CHEMBL4159169)
Affinity DataIC50:  104nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells at holding potential of -125 mV after 10 mins by patchxpress-based electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077787(CHEMBL3416937)
Affinity DataIC50:  110nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by whole cell patch clamp electrophysiology methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077779(CHEMBL3416944)
Affinity DataIC50:  110nMAssay Description:Inhibition of human NaV1.4 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50077787(CHEMBL3416937)
Affinity DataIC50:  110nMAssay Description:Inhibition of human NaV1.4 at -140 mV holding potential by whole-cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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